Mots-c

MOTS-c is a research-grade mitochondrial-derived peptide investigated for its roles in metabolic regulation, exercise mimetic effects, and healthy aging in cellular and animal models. Encoded by the mitochondrial 12S rRNA region, MOTS-c participates in stress-response signaling between mitochondria and the nucleus, especially under metabolic load and exercise conditions.​

Metabolic And Insulin Sensitivity Effects

• Enhances glucose uptake and insulin sensitivity by activating AMPK and promoting GLUT4 translocation in skeletal muscle, with studies showing improved glucose tolerance and reduced insulin resistance in high-fat-diet mice.​

• Modulates fatty acid oxidation and lowers dicarboxylic acids, indicating more efficient mitochondrial beta-oxidation and overall improved metabolic homeostasis in preclinical models.​

Exercise-Mimetic And Performance Research

• Circulating MOTS-c levels rise during and after exercise in humans, suggesting it functions as an exercise-induced peptide that contributes to training adaptations and mitohormesis.​

• Exogenous MOTS-c administration has been shown to improve endurance, running time, and metabolic flexibility in aged mice, positioning it as an exercise-mimetic candidate for performance and longevity studies.​

Longevity, Inflammation, And Organ Protection

• Demonstrates anti-inflammatory and cytoprotective actions via AMPK activation and MAPK pathway modulation, with research exploring applications in aging, cardiovascular disease, and insulin-resistant states.​

• Emerging data indicate potential benefits for bone metabolism, cardiomyocyte protection, and preservation of mitochondrial function in disease and aging models.​

For research purposes only. Not intended for human consumption