Epitalon

Epitalon is a research-grade synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from pineal gland peptide work, investigated for its roles in telomere maintenance, circadian regulation, and geroprotective signaling in cellular and animal models. It is commonly explored in longevity, neuroendocrine, and immune-aging studies as a multi-pathway modulator rather than a single-target agent.

Telomeres And Cellular Aging

• Upregulates hTERT expression and telomerase activity in normal human cells, leading to measurable telomere lengthening and extended replicative lifespan in vitro, while not significantly boosting telomerase activity in studied cancer lines.

• Demonstrates lifespan extension and delayed onset of age-related biomarkers in multiple animal models, supporting its use in research on cellular senescence and DNA stability.

Melatonin, Circadian Rhythm, And Sleep

• In aged primates and humans, Epitalon has been shown to increase melatonin production and normalize cortisol rhythms, suggesting restoration of pineal function and circadian timing.

• Modulates expression of clock genes such as Clock, Cry2, and Csnk1e, indicating direct action on molecular circadian machinery beyond simple hormone replacement.

Antioxidant, Immune, And Neuroprotective Effects

• Enhances endogenous antioxidant defenses by stimulating enzymes like superoxide dismutase and reducing lipid peroxidation, thereby lowering oxidative stress in brain and systemic tissues.

• Rebalances age-altered immune markers (including IL‑2 expression) and shows protective effects in pineal, retinal, and neural tissues, making it relevant for neurodegeneration and immunosenescence research.

For research purposes only. Not intended for human consumption or any medical use.