GHK-Cu (Copper Peptide) 1g Raw Powder

GHK‑Cu (glycyl-L-histidyl-L-lysine copper(II)) is a research-grade naturally occurring copper-binding tripeptide first isolated from human plasma, where it functions as a potent biological signal with roles in tissue remodeling, wound healing, anti-inflammatory regulation, and gene expression modulation. The coordination of copper(II) by the histidine and terminal amine residues is essential for its bioactivity, enabling GHK‑Cu to influence a remarkably broad range of cellular processes. Available in 1g raw powder format for research applications requiring larger quantities or custom formulation.

Tissue Regeneration and Wound Healing Research

• Stimulates synthesis of collagen, elastin, dermatan sulfate, and chondroitin sulfate in fibroblast models, supporting investigations into extracellular matrix remodeling and connective tissue repair under both normal and pathological conditions.
• Promotes the proliferation and migration of keratinocytes and endothelial cells in scratch assay and wound closure models, with concurrent upregulation of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) expression.
• Demonstrated acceleration of wound closure in diabetic and non-diabetic rodent models, making it a widely employed positive control in preclinical wound healing study designs.

Gene Expression and Proteasome Activity

• Microarray and RNA-seq studies reveal GHK‑Cu influences expression of over 4,000 human genes, predominantly upregulating pathways associated with tissue repair, antioxidant defense, and anti-inflammatory signaling while downregulating genes implicated in cancer progression and inflammatory cytokine cascades.
• Activates proteasome activity in aging fibroblast models, restoring impaired protein degradation capacity associated with cellular senescence — a key mechanism studied in the context of proteostasis and age-related tissue dysfunction.

Anti-Inflammatory and Antioxidant Research

• Inhibits TNF‑α, IL‑1β, and IL‑6 production in lipopolysaccharide-stimulated macrophage models; also investigated for its ability to block free radical damage to cell membranes through copper-catalyzed superoxide dismutase (SOD)-mimetic activity.
• Studied in neuroinflammation models for neuroprotective effects, including reduced oxidative stress markers and preservation of neuronal viability under excitotoxic challenge.

Hair Follicle Biology

• Stimulates hair follicle size, prolongs anagen phase, and increases follicle-derived IGF‑1 in ex vivo and in vivo models; co-investigated with AHK‑Cu for synergistic effects on follicle miniaturization reversal and dermal papilla cell proliferation.

Purity and Presentation

• Supplied as a 1g raw lyophilized powder for bulk research formulation. Verified ≥99% purity by HPLC. Third-party tested for identity, heavy metal content, and sterility.

For research purposes only. Not intended for human consumption, disease prevention, diagnosis, or any therapeutic use. This product is intended solely for in vitro and laboratory research.

Research Guide

For a detailed scientific overview of this compound, read our research guide.